Parkinson’s Institute and Clinical Center and Axial Biotherapeutics Announce Collaboration to Target Gastrointestinal Metabolites That May Contribute to Parkinson’s Disease

Parkinson’s Institute and Clinical Center (PICC) and Axial Biotherapeutics announced a collaboration to investigate interventions targeting gastrointestinal (GI) metabolites that may cause Parkinson’s Disease (PD). The interventions, to be developed and identified by Axial, will build on the work of Axial’s scientific Co-founder and Caltech Professor, Sarkis Mazmanian, Ph.D. Axial’s unique approach to PD interventions is inspired by the effects the microbiome and its metabolites have on PD progression.

As part of the collaboration, Axial and the PICC have formed a joint preclinical research collaboration, studying Axial’s microbiome-inspired interventions in the PICC’s unique cellular and animal models for PD and its effects over the GI system.

“Our team is conducting advanced clinical research, which suggests that disorders like Parkinson’s are not just a brain condition but very likely have origins in the GI system,” said Carrolee Barlow, M.D., Ph.D., Chief Executive Officer, Parkinson’s Institute and Clinical Center. “We are excited to join forces with Axial Biotherapeutics and their team to investigate an intervention with the potential to eradicate and block these microbial effects and improve GI function. It is our ultimate goal to determine if this approach can stop PD from progressing. Partnerships like this, along with financial donations, will make our goal of finding a solution for PD a reality.”

In parallel to the newly formed collaboration, Dr. Barlow has joined Axial’s recently formed Neurology Scientific and Clinical Advisory Board, and will help guide the Company’s clinical programs.

“The collaboration with Dr. Barlow and her team at the PICC is expected to significantly increase the pace of development for our approach to PD,” added David H. Donabedian, PhD, Co-founder and CEO of Axial Biotherapeutics. “We truly appreciate the enthusiasm and collaborative spirit exhibited by Dr. Barlow and her team, and we look forward to seeing the fruits of this partnership, which will hopefully bring us several steps closer to finding a better solution for this disease.”